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We elected not to propose use of a historical lookback approach (under options 1 and 2) because ASP units are often missing, negative, or equal to zero for the most recent calendar quarter and/or over several quarters in a four-quarter lookback period, and so including additional quarters may not necessarily yield additional data that could be used to apportion inflation rebate amounts (and could complicate the calculation of an average by introducing a mix of missing units, negative units, or units equal to zero, and positive units within a single NDC)

Weight loss injections have been shown to produce significant and sustainable weight loss when combined with healthy lifestyle changes

Many consumers prefer options that contain only water and carbon dioxide

Collagen peptides have more human data on knee osteoarthritis symptoms, but even there, results are mixed and effect sizes are often modest